科研成果
目前发表学术论文90多篇，论文被他引用次数达二千二百余次。申请专利12项（其中五项已获授权），参编书籍5部，作为项目负责人，先后承担和完成国家、省部级科研目项十多项。参见国际国内学术会议，被邀请做大会及口头报告近三十余次。
近年发表期刊论文
1. Hua Cai, Jing Nie, Yan Zheng, andJun-An Ma*, Lithium Binaphtholate-Catalyzed Enantioselective Enyne Addition to Ketones: Access to Enynylated Tertiary Alcohols,J. Org. Chem.2014,79, 5484–5493.
2. Fa-Guang Zhang, Yi Wei, Yu-Ping Yi, Jing Nie, andJun-An Ma*, Regioselective Cycloaddition of Trifluorodiazoethane with Electron-Deficient Allenic Esters and Ketones: Access to CF3‑Substituted Pyrazolines and Pyrazoles,Org. Lett.2014,16, 3122–3125.
3. Jun-An Ma* and Shen Li, Catalytic fluorination of unactivated C(sp3)–H bonds,Org. Chem. Front.2014,1, 712–715.
4. Heng-Xia Zhang, Jing Nie, Hua Cai, andJun-An Ma*,Cyclic Aldimines as Superior Electrophiles for Cu-Catalyzed Decarboxylative Mannich Reaction of β-Ketoacids with a Broad Scope and High Enantioselectivity,Org. Lett.2014,16, 2542–2545.
5. Li-Jun Yang, Shen Li, Shuai Wang, Jing Nie, andJun-An Ma*, Nucleophilic Lewis Base Dependent Addition Reactions of Allenoates with Trifluoromethylated Cyclic Ketimines.J. Org. Chem.2014,79, 3547–3558.
6. Shuai Wang, Jing Nie, Yan Zheng, andJun-An Ma*, A Direct Copper-Promoted Three-Component Entry to Trifluoromethylketoximes,Org. Lett.2014,16, 1606–1609.
7. Ke-Feng Zhang, Jing Nie, Ran Guo, Yang Zheng,Jun-An Ma*, Chiral Phosphoric Acid-Catalyzed Asymmetric Aza-Friedel–Crafts Reaction of Indoles with Cyclic N-Acylketimines: Enantioselective Synthesis of Trifluoromethyl-dihydroquinazolines,Adv. Synth. Catal.2013,355, 3497–3502.
8. Hai-Na Yuan, Shen Li, Jing Nie, Yan Zheng, and Jun-An Ma, Highly Enantioselective Decarboxylative Mannich Reaction of Malonic Acid Half Oxyesters with Cyclic Trifluoromethyl Ketimines: Synthesis of β-Amino Esters and Anti-HIV Drug DPC 083,Chem. Eur. J.2013,19, 15856–15860.
9. Li-Jun Yang, Shuai Wang, Jing Nie, Shen Li, andJun-An Ma*, Bisphosphine-Triggered One-Pot Sequential [3 + 2]/[3+ 2] Annulation of Allenoates with Cyclic Ketimines,Org. Lett.2013,15, 5214-5217.
10. Feng Li, Jing Nie, Long Sun, Yan Zheng,Jun-An Ma*, “Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles”,Angew. Chem. Int. Ed.2013,52, 6375–6378.
11. Hai-Na Yuan, Shuai Wang, Jing Nie, Wei Meng, Qingwei Yao, andJun-An Ma*, Hydrogen-Bond-Directed Enantioselective Decarboxylative Mannich Reaction of β-Ketoacids with Ketimines: Application to the Synthesis of Anti-HIV Drug DPC 083,Angew. Chem. Int. Ed.2013,52, 3869–3873.
12. Wen-Ting Meng, Yan Zheng, Jing Nie, Heng-Ying Xiong,Jun-An Ma, Organocatalytic Asymmetric One-pot Sequential Conjugate Addition/ Dearomative-Fluorination: Synthesis of Chiral Fluorinated Isoxazol-5(4H)-ones,J. Org. Chem.2013,78, 559–567.
13. Tian-Lin Liu, Heng-Xia Zhang, Yan Zheng, Qingwei Yao, Jun-An Ma，Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines,Chem. Commun.2012,48, 12234–12236.
14. Feng Li, Long Sun, Yuou Teng, Peng Yu, John Cong-Gui Zhao,Jun-An Ma, Highly Diastereo- and Enantioselective Organocatalytic One-Pot Sequential 1,4-Addition/Dearomative-Fluorination Transformation,Chem. Eur. J.2012,18, 14255–14260.
15. Fa-Guang Zhang, Xiao-Yan Zhu, Shen Li, Jing Nie,Jun-An Ma*, Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083,Chem. Commun.2012,48, 11552–11554.
16. Wei Meng, Hai-Tao Zhao, Jing Nie, Yan Zheng, Aiping Fu,Jun-An Ma*, “Allenoate-derived 1,5-, 1,7-, and 1,9-zwitterions as highly versatile coupling partners for phosphine-triggered cycloaddition reactions”Chem. Sci.2012,3, 3053–3057.
17. Cui-Bo Liu, Wei Meng, Feng Li, Shuai Wang, Jing Nie,Jun-An Ma*, “A Facile Parallel Synthesis of Trifluoroethyl-Substituted Alkynes”,Angew. Chem. Int. Ed.2012,51, 6227–6230.
18. Jing Nie, Ming-Qing Hua, Heng-Ying Xiong, Yan Zheng,Jun-An Ma*, Asymmetric Phase-Transfer Catalyzed Conjugate Addition of Glycine Imine to Exocyclicα,β-Unsaturated Ketones: Construction of Polycyclic Imines Containing Three Stereocenters,J. Org. Chem.2012,77(9), 4209–4216.
19. Yan Zheng, Heng-Ying Xiong, Jing Nie, Ming-Qing Hua,Jun-An Ma*, Biomimetic Catalytic EnantioselectiveDecarboxylative Aldol Reaction ofβ-Ketoacids with Trifluoromethyl Ketones,Chem. Commun.2012,48, 4308–4310.
20. Fa-Guang Zhang, Hai Ma, Jing Nie, Yan Zheng, Qingzhi Gao,Jun-An Ma*, Enantioselective Diynylation of CyclicN-Acyl Ketimines: Access to Chiral Trifluoromethylated Tertiary Carbinamines,Adv. Synth. Catal.2012,354, 1422–1428.
21. Feng Li, Jing Nie, Jun-Wei Wu, Yan Zheng,Jun-An Ma*, Stereoselective Synthesis of Fluorinated 2,3-Dihydroquinolin-4(1H)-2-ones via a One-Pot Multistep Transformation,J. Org. Chem.2012,77, 2398–2406.
22. Tian-Lin Liu, Hai Ma, Fa-Guang Zhang, Yan Zheng, Jing Nie,Jun-An Ma*, Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols,Chem. Commun.2011,47, 12873–12875.
23. Lian Wang, Wei Meng, Chuan-Le Zhu, Yan Zheng, Jing Nie,Jun-An Ma*, The Long-Arm Effect: Influence of Axially Chiral Phosphoramidite Ligands on the Diastereo- and Enantioselectivity of the Tandem 1,4-Addition/Fluorination,Angew. Chem. Int. Ed.2011,50, 9442–9446.
24. Chuan-Le Zhu, Fa-Guang Zhang, Wei Meng, Jing Nie, Dominique Cahard,Jun-An Ma*, Enantioselective Base-Free Electrophilic Amination of Benzofuran-2(3H)-ones: Catalysis by Binol-Derived P-Spiro Quaternary Phosphonium Salts,Angew. Chem. Int. Ed.2011,50, 5869–5872.
25. Guang-Wu Zhang, Wei Meng, Hai Ma, Jing Nie, Wen-Qin Zhang,Jun-An Ma*, “Catalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects, Observation and Practical Implications of Zinc-to-Titanium Transmetalation”,Angew. Chem. Int. Ed.2011,50, 3538–3542.
26. Ming-Qing Hua, Lian Wang, Han-Feng Cui, Jing Nie, Xiao-Ling Zhang,Jun-An Ma*, A powerful synergistic effect for highly efficient diastereo- and enantioselective phase-transfer catalyzed conjugate additions,Chem. Commun.2011,47, 1631–1633.
27. Jing Nie, Hong-Chao Guo, Dominique Cahard, Jun-An Ma*, Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates,Chem. Rev.2011,111, 455–529.
28. Ming-Qing Hua, Han-Feng Cui, Lian Wang, Jing Nie,Jun-An Ma*, Reversal of Enantioselectivity by Tuning the Conformational Flexibility of Phase-Transfer Catalysts,Angew. Chem. Int. Ed.2010,49, 2772–2776.
29. Hai Ma, Kun Liu, Fa-Guang Zhang, Chuan-Le Zhu, Jing Nie,Jun-An Ma*, Chiral Bifunctional Thiourea-Catalyzed Enantioselective Michael Addition of Ketones to Nitrodienes,J. Org. Chem.2010,75, 1402–1409.
30. Guang-Wu Zhang, Dong-Hua Zheng, Jing Nie, Teng Wang,Jun-An Ma*, Brønsted Acid-catalyzed Efficient Strecker Reaction of Ketones, Amines and Trimethylsilyl Cyanide,Org. Biomol. Chem.2010,8,1399–1405.
31. J. Nie, G.-W. Zhang, L. Wang, A. Fu, Y. Zheng,Jun-An Ma*,A perfect double role of CF3groups in activating substrates and stabilizing adducts: the chiral Brøsted acid-catalyzed direct arylation of trifluoromethyl ketones,Chem. Commun.,2009, 2356–2358.
32. Jun-An Ma, Dominique Cahard, Update: Asymmetric Fluorination, Trifluoromethylation and Perfluoroalkylation,Chem. Rev.2008,108(9), PR1–43.
33. Guang-Wu Zhang, Lian Wang, Jing Nie,Jun-An Ma*,Chiral Brønsted Acid-Mediated Enantioselective Organocatalytic Three-component Reaction for the Construction of Trifluoromethyl-containing Molecules,Adv. Synth. Catal.2008,350,1457–1463.
34. Jing Nie, Hong-Wei Zhu, Han-Feng Cui, Ming-Qing Hua,Jun-An Ma*, Catalytic Stereoselective Synthesis of Highly Substituted Indanones via Tandem Nazarov Cyclization and Electrophilic Fluorination Trapping,Org. Lett.2007,9, 3053–3056.
35. Han-Feng Cui, Ke-Yan Dong, Guang-Wu Zhang, Lian Wang,Jun-An Ma*, Stereoselective Construction of Fluorinated Indanone Derivatives via a Triple Cascade Lewis Acid-Catalyzed Reaction,Chem. Commun.2007, 2284–2286.
36. Kun Liu, Han-Feng Cui, Jing Nie, Ke-Yan Dong, Xiao-Juan Li,Jun-An Ma*, Highly Enantioselective Michael Addition of Aromatic Ketones to Nitroolefins Promoted by Chiral Bifunctional Primary Amine-thiourea Catalysts Based on Saccharides,Org. Lett.2007,9, 923–925.
37. Jun-An Ma*, Catalytic Asymmetric Synthesis of α- and β-Amino Phosphonic Acid Derivatives,Chem. Soc. Rev.2006,35, 630–636.
38. Hong-Chao Guo,Jun-An Ma*, Catalytic asymmetric tandem transformations triggered by conjugate addition,Angew. Chem. Int. Chem.2006,45, 354–366.
39. M. T. Reetz*,Jun-An Ma, R. Goddard, BINOL-derived monodentate phosphites and phosphoramidites with P-sterogenic centers: novel ligands for transition metal catalysis,Angew. Chem. Int. Ed.2005,44, 412–415.
40. Jun-An Ma, Dominique Cahard, Asymmetric Fluorination, Trifluoromethylation and Perfluoroalkylation,Chem. Rev.2004,104(12), 6119–6146.
41. Jun-An Ma, Dominique Cahard, Towards perfect catalytic asymmetric synthesis: dual activation for the electrophiles and the nucleophiles,Angew. Chem. Int. Ed.2004,43, 4566–4583.
42. Jun-An Ma*, Recent Developments in Catalytic Asymmetric Synthesis ofa- andb-Amino Acids,Angew. Chem. Int. Ed.2003,42, 4290–4299.
